Amyloidosis

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Primary amyloidosis is a disorder in which abnormal proteins build up in tissues and organs. Clumps of the abnormal proteins are called amyloid deposits. Primary amyloidosis can lead to conditions that include:Carpal tunnel syndrome;Heart muscle damage (cardiomyopathy) leading to congestive heart failure;Intestinal malabsorption;Liver enlargement;Kidney failure;Nephrotic syndrome;Neuropathy (nerves that do not work properly);Orthostatic hypotension (abnormal drop in blood pressure with standing);The deposits build up in the affected organs, causing them to become stiff, which decreases their ability to function. An amyloid tissue deposition disease that may have a primary cause or be secondary to other diseases. Usually presents with unexplained weight loss, fatigue, and edema resistant to diuretic therapy. Immunofixation of the serum and urine confirms the presence of monoclonal light chains in primary systemic amyloidosis. Biopsy verification of amyloid deposits is essential. Treatment includes appropriate management of resulting clinical syndromes, such as nephrotic syndrome, cardiomyopathy, and conduction disorders. Definitive treatment of primary systemic amyloidosis (AL amyloidosis) includes myeloablative high-dose chemotherapy with stem cell reconstitution in selected patients, or chemotherapy.

Symptoms:

Laboratory Test Procedures:

irregular heartbeat
fatigue
swollen tongue
numbness or tingling in the hands
numbness or tingling in the feet
shortness of breath
difficulty swallowing
painful swallowing
hands swelling
feet swelling
ankles swelling
weak hand grip
weight loss
decreased urine output
diarrhea
fatigue
hoarse voice
joint aches
discoloration
sores
boils
brittle nails

Protein (URINE TEST)
Protein, Total
RBC
Platelet Count
Albumin
Alkaline Phosphatase (ALP)
Troponin
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