Churg-Strauss syndrome (Wegener's Granulomatosis)

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Churg-Strauss syndrome (CSS) is a form of primary systemic autoimmune vasculitis characterized by inflammation of blood vessels. This inflammation can restrict blood flow to vital organs and tissues, sometimes permanently damaging them. In CSS, vasculitis is associated with asthma and eosinophilia. Affected people classically have perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) directed against myeloperoxidase (MPO). Asthma is the most common sign of Churg-Strauss syndrome, but Churg-Strauss syndrome can cause a variety of problems, ranging from hay fever, rash and gastrointestinal bleeding, to severe pain and numbness in your hands and feet. The wide range of symptoms, and their similarity to symptoms of other disorders, make Churg-Strauss syndrome challenging to diagnose. Churg-Strauss syndrome is rare and has no cure. The cause of the syndrome is not known, but it involves an abnormal over-activation of the immune system in a person with underlying bronchospastic lung disease (asthma). Doctors can usually help control symptoms with steroids and other powerful immunosuppressant drugs.

Symptoms:

Laboratory Test Procedures:

chest pain
shortness of breath
coughing up blood
difficulty breathing
coughing
coughing at night
wheezing or coughing after exercise
trouble sleeping
fever
fatigue
joint aches
muscle aches
weight loss
loss of appetite
numbness
sneezing
sweating
nodules under skin
diarrhea
nausea
vomiting
abdominal pain
blood in the vomit
bladder and prostate gland can become inflamed
numbness or tingling in the hands
numbness or tingling in the feet
pain, numbness, weakness or coldness in legs or arms
weak hand grip
seizures
confusion
irregular heartbeat
skin rash
blood in urine

Eosinophil %
Eosinophil Absolute
ANCA/MPO/PR3 Antibodies
ESR - Sed Rate
C-Reactive Protein (CRP)
Creatinine
BUN
Blood (URINE TEST)
Protein (URINE TEST)
RBC (erythrocytes) (URINE TEST)
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