Insulin Resistance (Metabolic syndrome)

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In insulin resistance, the body's cells have a diminished ability to respond to the action of the insulin hormone. To compensate for the insulin resistance, the pancreas secretes more insulin. Normally, food is absorbed into the bloodstream in the form of sugars such as glucose and other basic substances. The increase in sugar in the bloodstream signals the pancreas (an organ located behind the stomach) to increase the secretion of a hormone called insulin. This hormone attaches to cells, removing sugar from the bloodstream so that it can be used for energy. People with this syndrome have insulin resistance and high levels of insulin in the blood as a marker of the disease rather than a cause. A cluster of common abnormalities, including insulin resistance, impaired glucose tolerance, abdominal obesity, reduced HDL-cholesterol levels, elevated triglycerides, and hypertension. Incidence is increasing in line with the number of people who are overweight or obese, with one quarter of the Western population estimated to have the condition. Increases risk of cardiovascular disease and diabetes, although there are ethnic variations in the incidence of comorbidities associated with metabolic syndrome defined by the same criteria. Obesity, an atherogenic diet, and physical inactivity are the strongest risk factors for the development of metabolic syndrome. Statins are considered first-line treatment when lifestyle measures do not achieve the desired non-HDL-cholesterol levels. Fibrates also play a significant role in the modification of lipid levels. Lifestyle interventions, including a diet low in saturated fats and moderate to intense physical activity, are the mainstay of treatment. Insulin resistance may also be associated with hypoglycemia (autoimmune conditions)


Laboratory Test Procedures:

increased abdominal fat
high blood pressure
high cholesterol
cholesterol deposits in the eyelids
increased frequency of urination at night
increased urine output
excessive thirst
blurred vision
drastic appetite shifts
increased hunger

Follicle Stimulating Hormone (FSH)
Glucose Tolerance 2hr (75g)
Glucose Tolerance 3hr (75g)
Glucose Tolerance 3hr Preg (100g)
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