Felty syndrome

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Felty syndrome is a rare disorder that involves rheumatoid arthritis, a swollen spleen, decreased white blood cell count, and repeated infections. It is more common in people who have had rheumatoid arthritis for a long time. People with this syndrome are at risk of infection because they have a low white blood cell count. This is a rare, extra-articular manifestation of rheumatoid arthritis (RA), characterized by persistent, idiopathic neutropenia and, in some cases, splenomegaly. Estimated to occur in <1% of RA patients. Tends to occur in the fifth to seventh decades of life, typically in white patients who have had long-standing seropositive, erosive RA. Cause of neutropenia is multifactorial and is thought to result from an imbalance between neutrophil production in the bone marrow and increased destruction in the peripheral blood, or both. A clinical diagnosis with no specific diagnostic test; other causes of neutropenia should be excluded. Goal of therapy is to raise the neutrophil count and prevent recurrent infections, while controlling systemic rheumatoid disease activity.


Laboratory Test Procedures:

easy fatigue
loss of appetite
weight loss
pale skin
face swelling
joint aches
joint swelling
joint stiffness
joint redness
increased number and severity of infections
reddened eyes
swollen spleen
enlarged liver
swollen lymph nodes

Neutrophil %
Neutrophil Absolute
Platelet Count
Hypersegmented neutrophils
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All information on this page is intended for your general knowledge only and does not provide medical advice, diagnosis or treatment. See Additional Information